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The Senate on Thursday will move to repeal the Affordable Care Act, with Vice President Mike Pence and Speaker of the House Paul Ryan declaring victory over GOP lawmakers who were opposed to their effort to do so.
The Senate voted 45-43 to pass the measure.
Trump had previously urged lawmakers to repeal and replace the law, but Republicans were unable to muster the 60 votes necessary.
The vote comes just days before the deadline for Republicans to pass a sweeping budget that would help shore up the U.S. economy.
A new CBO score says the Senate repeal bill would leave 27 million more people without insurance than in the House version.
The CBO said the House bill would add more than $2 trillion in additional spending without adding to deficits.
Republicans are expected to use the vote to rollback President Barack Obama’s signature health care law.
The measure is expected to face fierce opposition in the Senate, with many Republicans expressing doubts about its effectiveness.
GOP lawmakers are expected once again to vote against the bill, which is a key component of Trump’s health care overhaul, after their efforts to defeat a repeal bill last year failed.
House Speaker Paul Ryan said on Thursday that Democrats are working to “cut the hell out of Obamacare.”
Trump on Thursday also called on Republicans to support a bill that he described as “the only one that’s going to actually get it done.”
Republicans also have yet to endorse a plan that would allow states to opt out of Medicaid expansion in 2018, a move that could give states more flexibility in covering lower-income people.
Ryan told reporters Thursday that he supports allowing states to make changes to their Medicaid programs to help them pay for lower costs for coverage.
The House passed a bill earlier this month that would give states flexibility in setting up a health care exchange, which would offer private health insurance to the public.
Trump has repeatedly said he wants to expand Medicaid to cover millions of people.